The treatment instrument (12) includes a first treatment part (52), a second treatment part (54), and an operation part (32). The first treatment unit includes a holding member (62, 64) that holds the living tissue to be joined and an energy release unit (82b, 84b) that joins the living tissue to be joined, and receives energy from the energy source. When applied, the living tissues to be joined are joined. The second treatment unit is sandwiched between the living tissues to be joined and denatures the surface that comes into contact with the living tissues to be joined. The operation unit is operated so that the holding member moves relatively. The energy release unit and the second treatment unit can detect at least one of the biological information of the biological tissue held by the holding member and the biological information of the biological tissue between the holding member and the second treatment unit, The energy output from the energy source to the energy emitting unit and the second treatment unit is controlled based on the biological information of the living tissue obtained by the energy emitting unit and the second treatment unit.治療用処置具（１２）は、第１の処置部（５２）と第２の処置部（５４）と操作部（３２）とを有する。第１の処置部は、接合対象の生体組織を保持する保持部材（６２，６４）と、接合対象の生体組織を接合するエネルギ放出部（８２ｂ，８４ｂ）とを有し、エネルギ源からエネルギを印加したときに接合対象の生体組織を接合する。第２の処置部は接合対象の生体組織の間に挟まれ接合対象の生体組織が接する面を変性させる。操作部は保持部材が相対的に移動するように操作する。エネルギ放出部および第２の処置部は、保持部材で保持した生体組織の生体情報、および、保持部材と第２の処置部との間の生体組織の生体情報の少なくとも一方を検出可能であり、エネルギ放出部および第２の処置部で得られた生体組織の生体情報に基づいてエネルギ源からエネルギ放出部および第２の処置部に出力されるエネルギが制御される。
