DERIVES COMBRETASTATINE CONTENANT UNE FONCTION FLUOROALKYLOXY, LEUR PREPARATION ET LEUR UTILISATION

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专利权人:

ZHEJIANG DADE PHARMACEUTICAL GROUP CO. LTD.

发明人:

SHEN, WEIPING,WANG, JIANPING,WANG, JIANGUO,JIN, HONGMEI,QIAN, FENG,WANG, FEI

申请号：

CA2660760

公开号：

CA2660760C

申请日:

2006.11.22

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

The present invention disclosed a class of new derivatives of CombretastatinofFormula (I) obtained by total synthesis. The strategy developed for each ofthe compounds, isto introduce a fluoroalkoxy to the 4'- position of the B aromatic ring innatural productCombretastatin, and meanwhile, functionally chemically modify the 3'-positionwith amino,nitro, halogen, alkoxy, phosphate, side chain of an amino acid etc. ComparedtoCombretastatin 4, said compounds show more activity in inhibiting the assemblyof tubulininto microtubules, and are useful as antitumor agent and/or anti-angiogenicagent.(see formula I)

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