It contains metadokishin (piridokisoru l 2 pyrolidone 5 karubokishireto) and the garlic oil, as the active ingredient pharmacy for the alcoholic characteristic fatty liver or prevention or remedy of the hepatitis, it regards the food or the beverage composition.SolutionsImprovement or recovery of the liver function which it is damaged by the prevention or remedy or alcoholic intake of the alcoholic characteristic fatty liver and the fatty liver characteristic hepatitis which as for the said pharmacy composition, as for combined use dosage of metadokishin and the garlic oil with this invention, accumulation of the triglyceride which is while liver organizing in comparison with the independence dosage of the metadokishin or garlic oil, and increase control in AST the blood (aspartic acid amino transferase), show the remarkable effect in the revelation control, and AMPK (AMP activated protein kinase) deactivation control of FAS (fatty acid synthetic enzyme), CYP2E1 and iNOS, (induction type nitrogen oxide synthetic enzyme) are induced with intake of alcoholIt can be utilized effectively for the sake of.< Selective figure >Figure 1メタドキシン(ピリドキソールl-2-ピロリドン-5-カルボキシレート)及びニンニク油を有効成分として含有する、アルコール性脂肪肝又は肝炎の予防又は治療のための薬学、食品、又は飲料組成物に関する。【解決手段】該薬学組成物は、本発明によるメタドキシン及びニンニク油の併用投与は、メタドキシンまたはニンニク油の単独投与に比べ、肝組織内のトリグリセリドの蓄積及び血中AST(アスパラギン酸アミノトランスフェラーゼ)の増加抑制、FAS(脂肪酸合成酵素)、CYP2E1及びiNOS(誘導型酸化窒素合成酵素)の発現抑制、及びAMPK(AMP活性化プロテインキナーゼ)失活抑制に顕著な効果を示し、アルコールの摂取で誘導されるアルコール性脂肪肝及び脂肪肝性肝炎の予防又は治療、またはアルコール摂取によって損傷した肝機能の改善または回復のために効果的に利用されうる。【選択図】図1
