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The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
专利权人:
The United States of America, as represented by the Secretary, Dept. of Health and Human Services;SRI INTERNATIONAL
发明人:
Wainer, Irving W.,Bernier, Michel,Toll, Lawrence Robert,Jimenez, Lucita Arenas
申请号:
AU2011224241
公开号:
AU2011224241A1
申请日:
2011.03.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
This disclosure concerns the discovery of the use of fenoterol and ()- and ()- fenoterol analogues for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2- adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analogue or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.
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