A hyper-oxygenated water composition comprising water and 10 ppm to 50 ppm of molecular oxygen, methods and systems of making and using the hyper-oxygenated water composition are described. The hyper-oxygenated water composition was made by pre-filtering and filtering by reverse osmosis of a source water, ozonolyzing and vortexing with oxygen with the water, ultraviolet irradiating and treating with hydrogen peroxide the water. The hyper-oxygenated water composition can be used for general improvement of human well-being and prevention and treatment of diseases by oral or transcutaneous administration of the hyper-oxygenated water composition.
