Jan GRIMM,Thomas REINER,Christian BRAND,Katja HAEDICKE
申请号：
US16347898
公开号：
US20190275179A1
申请日:
2017.11.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present technology provides compositions and nanoemulsions useful in optoacoustic imaging. A composition of the present technology includes at least one contrast agent covalently linked to a targeting agent； where the at least one contrast agent includes a dark quencher； the targeting agent includes an antibody, an antigen, an antigen-targeting ligand, a receptor ligand, or an adhesion peptide； and the at least one contrast agent and targeting agent are covalently linked by a linker of formula (I) X1-L1-X2 (I) where X1 is an amino, amide, S, or O of the at least one contrast agent； L1 is C1-C12 alkylene, C2-C12 alkenylene, C5-C12 cycloalkylene, or C6-C12 arylene； and X2 is an amino, amide, S, or O of the targeting agent.
