Provided is a pharmaceutical preparation comprising a DPP-IV inhibitor and metformin, wherein the DPP-IV inhibitor in the preparation is chemically stabilized. It contains a DPP-IV inhibitor and metformin or a salt thereof as active ingredients, and further contains a cyclic oligosaccharide, and the metformin or a salt thereof is granulated (the DPP-IV inhibitor and metformin or a salt thereof are cyclic oligosaccharides) A pharmaceutical preparation characterized in that it is mixed and granulated separately).DPP-IV阻害薬及びメトホルミンを含み、製剤中のDPP-IV阻害薬が化学的に安定化された医薬製剤を提供する。DPP-IV阻害薬及びメトホルミン又はその塩を有効成分として含み、更に環状オリゴ糖を含み、前記メトホルミン又はその塩が造粒されている（DPP-IV阻害薬とメトホルミン又はその塩とが環状オリゴ糖とは別に混合造粒されている場合を除く）ことを特徴とする、医薬製剤。
