PROBLEM TO BE SOLVED: To provide a pharmaceutical formulation of acidic pharmacologic agent which demonstrates improved uniformity of release over the wide range of pH values encountered between the stomach and intestinal tract.SOLUTION: The pharmaceutical formulation of acidic pharmacologic agent comprises an acidic pharmacologic agent dissolved or dispersed in a matrix comprising about 10-40 wt.% of a neutral water-swellable hydrophilic polymer and 20 wt.% to about 50 wt.% of an acid-soluble polymer which swells in water at pH values above about 5. A particularly preferred formulation comprises divalproex sodium. There are also provided a pre-tablet granulation and a method for producing both the pre-tablet granulation and the tablet unit dosage form.COPYRIGHT: (C)2012,JPO&INPIT【課題】胃と腸管の間で出会う広範囲のpH値にわたりより均一に放出される酸性薬物を含む医薬組成物の提供。【解決手段】酸性薬物を約10~約40重量%の中性水膨潤性親水性ポリマー及び20~約50重量%の約5を越えるpH値で水に膨潤する酸溶解性ポリマーからなるマトリックスに溶解または分散して含む。特に好ましい組成物はジバルプロエックスナトリウムを含む。錠剤化前顆粒、並びに錠剤化前顆粒及び錠剤の単位剤型の製造方法。【選択図】なし
