The application relates: to multilayered polymeric films comprising a first skin layer comprising at least one gas and vapor barrier organic polymer, a core layer that comprises at least one elastomeric organic polymer, and a second skin layer that comprises at least one sealable organic polymer and at least one antimicrobial agent to articles comprising the film useful in various applications such as medical and health care applications and to a method of providing a gas and vapor barrier with antimicrobial activity to an article comprising manufacturing an article comprising said film.