РИМКУС Катрин (DE),МУСКУЛУС Франк (DE),БРЮК Зандра (DE),ПЭТЦ Яна (DE)
申请号：
RU2011107140/15
公开号：
RU2011107140A
申请日:
2009.08.24
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical composition comprising N- [3-chloro-4 - [(3-fluorophenyl) methoxy] phenyl] -6- [5 [[[2- (methylsulfonyl) ethyl] amino] methyl] -2-furyl] - 4-quinazolinamine or a pharmaceutically acceptable salt thereof, in which a unit dosage of the composition contains from 1200 to 1300 mg of the active pharmaceutical ingredient, calculated on the free base. ! 2. The pharmaceutical composition according to claim 1, in which the active pharmaceutical ingredient is a ditosylate salt of N- [3-chloro-4 - [(3-fluorophenyl) methoxy] phenyl] -6- [5 [[[2- (methylsulfonyl) ethyl ] amino] methyl] -2-furyl] -4-quinazolinamine, preferably in the form of its monohydrate. ! 3. The pharmaceutical composition according to claim 1, in which the active pharmaceutical ingredient is characterized by a particle size of from 1 to 30 microns, preferably from 1 to 20 microns. ! 4. The pharmaceutical composition according to claim 1, in which the active pharmaceutical ingredient is characterized by a specific surface area of 5 to 10 m2 / g. ! 5. The pharmaceutical composition according to claims 1 to 4, which is in the form of an effervescent tablet. ! 6. The pharmaceutical composition according to any one of claims 1 to 4, which is in the form of a syrup. ! 7. The pharmaceutical composition according to any one of claims 1 to 4, which is in the form of granules suitable for suspension. ! 8. The pharmaceutical composition according to any one of claims 1 to 4, which is in the form of formulations suitable for the preparation of a suspension of pills. ! 9. A method of manufacturing a pharmaceutical composition according to any one of claims 1 to 8, comprising the step of milling or grinding the active pharmaceutical ingredient in the presence of one or more excipients.1. Фармацевтическая композиция, содержащая N-[3-хлор-4-[(3-фторфенил)метокси]фенил]-6-[5[[[2-(метилсульфонил)этил]амино]метил]-2-фурил]-4-хиназолинамин или его фармацевтически приемлемую соль, в которой стандартная дозиров
