SURLERAUX, DOMINIQUE LOUIS NESTOR GHISLAIN,WIGERINCK, PIET TOM BERT PAUL,GETMAN, DANIEL P.
申请号：
CA2492832
公开号：
CA2492832C
申请日:
2003.08.04
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to the use of 2-amino-benzothiazoles, having theformula (I) wherein R1 is hexahydrofuro[2,3-b]furanyl, tetrahydrofuranyl,oxazolyl, thiazolyl, pyridinyl, or phenyl optionally substituted with one ormore substituents independently selected from C1-6-alkyl, hydroxy, amino,halogen, aminoC1-4-alkyl and mono-or di(C1-4alkyl)amino R2 is hydrogen or C1-6alkyl L is a direct bond, -0-, C1-6alkanediyl-O- or -O-C1-6alkanediyl R3 isphenylC1-4alkyl R4 is C1-6alkyl R5 is hydrogen or C1-6alkyl R6 is hydrogenor C1-6alkyl in the manufacture of a medicament useful for inhibiting mutantHIV protease in a mammal infected with said mutant HIV protease. It alsorelates to novel compounds of formula (I).
