JIANG, ZI-HUA,LEWICKY, JORDAN DAVID,WEIR, GENEVIEVE MARY,RAJAGOPALAN, RAJKANNAN,SAMMATUR, LEELADHAR,STANFORD, MARIANNE MICHELLE,MANSOUR, MARC
申请号：
CA2972635
公开号：
CA2972635A1
申请日:
2015.12.11
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention provides lipid A mimics in which one or both of the sugar residues of a natural lipid A disaccharide backbone has been replaced with an aromatic group. These lipid A mimics may further differ from a natural lipid A molecule with respect to other structural characteristics, such as, a different number of phosphate groups present, changes in the number, structure and location of lipid chains and/or changes in the spacing and linkage of the sugar residues (or their aromatic replacements). The lipid A mimics may be lipid A agonists and as such may be useful as immunostimulatory agents in inducing or patenting an antibody and/or cell-mediated immune response, or may be lipid A antagonists and as such may be useful in treating or preventing a lipopolysaccharide (LPS)/lipid A-mediated disease or disorder. Also provided are methods for preparing the lipid A mimics.
