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MODIFICATION OF INTRINSICALLY DISORDERED SEQUENCES FOR THE PREPARATION OF VACCINES
专利权人:
MALINA; HALINA H.M.
发明人:
MALINA, HALINA H.M.
申请号:
CA2700466
公开号:
CA2700466C
申请日:
2010.04.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The intrinsically disordered sequences - or "intrinsic disorder sequences" or IDSeq - proteins should be flexible to ensure a controlled interaction between proteins. In the development of the diseases, IDSeq are modified and polymerized. The invention describes the method of preparation of the drugs against cancers, the degenerative diseases and the infectious illness, by the induction of an immune reaction against IDSeq modified in a covalent way (IDSeqC) and polymerized (pIDSeqC), and leading to a new network of protein signaling, named here "misfoldome", causing the diseases. The invention describes the preparation of vaccines by the use of polymers of IDSeqC. Peptides of the pIDSeqC are prepared in vitro, and introduced into a living organism to induce an immunological response, which eliminates the "misfoldome" and cures the diseases. The method is employed for the preparation of active or passive vaccines. The technology is adapted to detect, prevent or cure the diseases associated with ageing such as the degenerative diseases, cancers, and infections.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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