SPharmaceutical compositions and single unit dosage forms of () 3 (4 ((4 (morpholinomethyl)benzyl)oxy) 1 oxoisoindolin 2 yl)piperidine 2 6 dione or a pharmaceutically acceptable stereoisomer prodrug salt solvate hydrate or clathrate are provided herein. Also provided are methods of treating managing or preventing various disorders such as cancer an inflammatory disease and/or an immune related disorder.