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Long interfering nucleic acid duplexes targeting multiple RNA targets
专利权人:
发明人:
Dong Liang,David Sweedler,Kunyuan Cui
申请号:
US14826818
公开号:
US09777278B2
申请日:
2015.08.14
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Long interfering nucleic acid (iNA) duplexes, which are at least 30 nucleotides in length, which have at least one nick or nucleotide gap in the antisense or the sense strands or in both the sense and antisense strands. These long iNA duplexes do not induce an interferon response when transfected into mammalian cells. The antisense strands can target two separate mRNAs or two segments of one mRNA.
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