The present invention relates to an HPPD-inhibitor resistant HPPD enzyme comprising an amino acid sequence QIKECQ and a sequence F, (D/E), F, (M/L), W1, (P/A), P, W2, X, X, Y, Y wherein W1 is either A or P and where (i) if W1 is A then W2 is P, A, Q or L or, (ii) if W1 is P then W2 is P, A, Q or T, and wherein X is any amino acid. The invention also includes methods of identifying HPPD inhibitor resistant HPPD enzymes and also of the enzymes thus identified. Further, the invention relates to methods for selecting polynucleotides which comprise a region encoding a triketone specific resistant HPPD enzymes.