The present application provides at least one compound selected from compounds of Formula (I) stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein the variables R1, R2, R3, R4, L, W, R7, Y, Z, R', R'' and * are as defined herein. These compounds have good selectivity of T790M vs WT EGFR inhibition and are useful for treating disorders mediated thereby. The present application also provides pharmaceutical compositions comprising the same, processes for the preparation thereof, and the use thereof in therapy.本發明提供至少一種化合物，係選自式(I)、式(I)之立體異構體及式(I)之藥用鹽，其中變數R1、R2、R3、R4、L、W、R7、Y、Z、R'、R''和* 如本發明中所定義。這些化合物相對於WT EGFR抑制對T790M具有良好選擇性且用於治療由其介導的病症。本發明還提供了包含它們的藥物組合物、它們的製備方法以及它們在療法中的用途。
