SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;QILU PHARMACEUTICAL CO., LTD
发明人:
YONG GAN,CHUNLIU ZHU,QINGMIN YANG,XIAOQING ZHENG,LI GAN,XINXIN ZHANG,JINGYI WANG
申请号：
GB201211226
公开号：
GB2488731A
申请日:
2010.11.22
申请国别(地区):
GB
年份:
2012
代理人:
摘要：
A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises rigid membrane, push layer, drug layer, separating layer and aesthetic coating is disclosed. The rigid membrane contains semi-permeable polymer, hole-forming agent and/or plasticizer and has one or more delivery orifices on one end. The push layer comprises expanding material, permeation-promoter, binder, colorant and lubricant. The drug layer contains pharmaceutical active component, hydrophilic polymer carrier, permeation-promoter, colorant, lubricant and antistatic agent. The separating layer is between the inner surface of the rigid membrane and core comprised of drug layer and push layer and contains hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows increased release at initial stage and keeps constant release at late stage.
