PROBLEM TO BE SOLVED: To provide multilamellar vesicle preparations which can be produced easily without using an organic solvent, such as chloroform, or without using a phospholipid and which are excellent in stability； and to provide external preparations and cosmetics which contain the preparations.SOLUTION: The present invention provides a multilamellar vesicle preparation which contains a compound represented by formula (1), a bioactive substance, and water； and an external preparation and a cosmetic which contain the preparation. [Rand Rare each independently an alkyl group of C5 to 21, or an alkenyl group of C5 to 21； Rand Rare each independently H, an alkyl group of C1 to 22, or an alkenyl group of C2 to 22； z is an integer of 0 or more； and x and y are each independently an integer of 2-4.]SELECTED DRAWING: None【課題】クロロホルム等の有機溶剤やリン脂質を用いることなく、簡便に製造することができ、安定性に優れたマルチラメラベシクル製剤、及び該製剤を含有する外用剤並びに化粧料の提供。【解決手段】式（１）で示される化合物、生理活性物質、及び水を含有するマルチラメラベシクル製剤、及び該製剤を含有する外用剤並びに化粧料。［Ｒ１及びＲ２は、各々独立して、Ｃ５～２１のアルキル基又はＣ５～２１のアルケニル基；Ｒ３及びＲ４は、各々独立して、Ｈ、Ｃ１～２２のアルキル基又はＣ２～２２のアルケニル基；ｚは０以上の整数；ｘ及びｙは、各々独立して、２～４の整数］【選択図】なし
