COMPOSE 2-AMINO -6-FLUORO-N- [5-FLUORO-PYRIDIN -3-YL]PYRAZOLO [1,5-A]PYRIMIDINE-3-CARBOXAMIDE UTILE COMME INHIBITEUR DE LA KINASE ATR, SA PRÉPARATION, DIFFÉRENTES FORMES SOLIDES ET DÉRIVÉS RADIOMARQUÉS DE CELUI-CI

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专利权人:

Vertex Pharmaceuticals Inc.

发明人:

申请号：

EP14815187.1

公开号：

EP3077397B1

申请日:

2014.12.05

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention； methods of treating of various diseases, disorders, and conditions using the compounds of this invention； processes for preparing the compounds of this invention； intermediates for the preparation of the compounds of this invention； and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

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