OGBOURNE, Steven,THOMAS, David,MOSELEY, Ryan,AYLWARD, James
申请号：
ES10740847
公开号：
ES2633755T3
申请日:
2010.02.12
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A method for the cosmetic treatment of chronologically aged and / or photoaged non-diseased skin in a subject, comprising administering to the skin of said subject an isolated ingenol compound or a pharmaceutically acceptable salt thereof, in which the ingenol compound has the formula : ** (See formula) ** in which R1 is selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted acyl, optionally substituted aryl, optionally substituted arylalkyl, S (O) 2R ', S (O ) 2OR ', P (O) (OR') 2 (where R 'is hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl, or arylalkyl) and glycosyl and R2-R3 are independently selected from hydrogen, optionally substituted alkyl , optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted acyl, optionally substituted aryl, optionally substituted arylalkyl, S (O) 2R ', S (O) 2OR', P (O) (OR ') 2 (in the s that R 'is hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl, or arylalkyl) and glycosyl or R1 and R2 or R2 and R3 can form a methylene or ethylene chain； and R4 is selected from hydrogen, hydroxy, optionally substituted alkoxy, optionally substituted alkenoxy, optionally substituted alkyloxy, optionally substituted acyloxy, optionally substituted arylalkoxy, OS (O) 2R ', OS (O) 2OR', OP (O) (OR ' ) 2 (where R 'is hydrogen, alkyl, alkenyl, alkynyl, acyl, aryl, or arylalkyl) and glycoxy, in which the optional substituents for alkyl, alkenyl, alkynyl, aryl, arylalkyl, aryl and thus acyl , include: halo (chlorine, bromine, iodine and fluorine), hydroxyl, alkoxy, C1-6 alkyl, C3-6 cycloalkyl, phenyl, nitro, halomethyl (for example, tribromomethyl, trichloromethyl, trifluoromethyl), halomethoxy (for example, trifluoromethoxy , tribromomethoxy,), C (O) C1-6 alkyl, amino (NH2), C1-6 alkylamino, (for example, methylamino, ethylamino and propylamino) C1-6 dialkylamino (for example, dimethylamino, diethylamino and dipropylamino), CO2H , CO2 C1-6 alkyl, thio (SH
