Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including truncations and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from increased thrombopoiesis, such as thrombocytopenia.Linvention porte sur des compositions thrombopoïétiques comprenant des polypeptides de tyrosyl-ARNt synthétase, comprenant des troncations et/ou des variants de ceux-ci. Linvention porte également sur des procédés dutilisation de telles compositions dans le traitement daffections qui bénéficient dune thrombopoïèse accrue, telle quune thrombocytopénie.
