BERDINI, VALERIO,SAXTY, GORDON,MURRAY, CHRISTOPHER WILLIAM,BESONG, GILBERT EBAI,HAMLETT, CHRISTOPHER CHARLES FREDERICK,WOODHEAD, STEVEN JOHN,LIGNY, YANNICK AIMÉ EDDY,ANGIBAUD, PATRICK RENÉ
申请号：
ES11805567
公开号：
ES2541493T3
申请日:
2011.11.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I): ** Formula ** including any tautomeric or stereochemically isomeric form thereof, in which n represents an integer equal to 0, 1, 2, 3 or 4； R 1 represents hydrogen, C 1-6 alkyl, C 2-4 alkenyl, C 1-6 hydroxyalkyl, C 1-6 haloalkyl, C 1-6 hydroxyhaloalkyl, C 1-4 cyanoalkyl, C 1-6 alkoxyC 1-6 alkyl at which each C 1-6 alkyl can be optionally substituted with one or two hydroxyl groups, C1-6 alkyl substituted with -NR4R5, C1-6 alkyl substituted with -C (>； = O) -NR4R5, -S (>； = O) 2-C1-6 alkyl, - S (>； = O) 2-C1-6 haloalkyl, -S (>； = O) 2-NR14R15, C1-6 alkyl substituted with -S (>； = O) 2-C1-6 alkyl, C1-6 alkyl substituted with -S (>； = O) 2-C1-6 haloalkyl, C1-6 alkyl substituted with -S (>； = O) 2-NR14R15, C1-6 alkyl substituted with -NH- S (>； = O) 2-C1 alkyl -6, C1-6 alkyl substituted with -NH-S (>； = O) 2-haloalkyl C1-6, C1-6 alkyl substituted with -NR12-S (>； = O) 2-NR14R15, R6, C1-6 alkyl substituted with R6, C1-6 alkyl substituted with -C (>； = O) -R6, C1-6 hydroxyalkyl substituted with R6, C1-6 alkyl substituted with -Si (CH3) 3, C1-6 alkyl substituted with -P ( >； = O) (OH) 2 or C 1-6 alkyl substituted with - P (>； = O) (C 1-6 alkyl) 2； each R1a is independently selected from hydrogen, C1-4 alkyl, C1-4 hydroxyalkyl, C1-4 alkyl substituted with amino or mono or di (C1-4 alkyl) amino o-NH (C3-8 cycloalkyl), cyan C1-4alkyl , C1-4 alkoxy C1-4 alkyl, and C1-4 alkyl substituted with one or more fluorine atoms； each R2 is independently selected from hydroxyl, halogen, cyano, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C1-4 hydroxyalkyl, C1-4 hydroxyalkoxy, C1-4 haloalkyl, C1- haloalkoxy 4, hydroxyhaloalkyl C1-4, hydroxyhaloalkoxy C1-4, alkoxy C1-4alkyl C1-4, haloalkoxy C1-4alkyl C1-4, C1-4alkoxy C1-4alkyl in which each C1-4alkyl may be optionally substituted with one or two hydroxyl groups, hydroxyhaloalkoxy C1-4alkyl C1-4, R'3, C1-4 alkyl substituted with R'3, C1-4 alkyl substituted with -C (>； = O) -R13
