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Hydantoin derivatives as inhibitors of cell necrosis
专利权人:
The Brigham and Women's Hospital, Inc.;President and Fellows of Harvard College
发明人:
Cuny, Gregory,Yuan, Junying,Jagtap, Prakash,Degterev, Alexei
申请号:
ES10011481
公开号:
ES2567135T3
申请日:
2004.08.30
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of the formula: ** Formula ** a stereoisomeric form thereof, an acid addition salt or pharmaceutically acceptable base thereof; where X represents O; Y represents NH; R1, R2, and R3 independently represent H, OR8, F, Cl, Br, I, N (R8) 2, CO2R8, NO2, NHC (O) R8, alkyl having 1 to 10 carbons, or substituted alkyl having 1 at 10 carbons; R4 represents OR8, F, Cl, Br, I, N (R8) 2, CO2R8, NO2, NHC (O) R8, methoxy, alkyl having 1 to 10 carbons, or substituted alkyl having 1 to 10 carbons; R5 and R7 independently represent H or alkyl having 1 to 10 carbons; R6 represents alkyl having 1 to 10 carbons; R8 represents H, alkyl having 1 to 10 carbons, substituted alkyl having 1 to 10 carbons, alkenyl having less than 12 carbons, or alkynyl having less than 12 carbons; R9, R10, R9 ', R10', independently represent H, F, Cl, Br, I, alkyl having 1 to 10 carbons, substituted alkyl having 1 to 10 carbons, or a three to six membered cycloalkyl or substituted cycloalkyl which includes Cn and / or Cn '; and n and n 'is equal to an integer from zero to five; and wherein the substituted groups comprise one or more substituents selected from halogen, alkyl having 1 to 10 carbons, alkenyl having less than 12 carbons, alkynyl having less than 12 carbons, cycloalkyl, hydroxyl, amino, nitro, sulfhydryl, imino , amido, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, ketone, aldehyde, ester, heterocyclyl, -CF3, and -CN.Un compuesto de la fórmula:**Fórmula** una forma esteroisomérica del mismo, una sal de adición ácida o base farmacéuticamente aceptable del mismo; en donde X representa O; Y representa NH; R1, R2, y R3 representan independientemente H, OR8, F, Cl, Br, I, N(R8)2, CO2R8, NO2, NHC(O)R8, alquilo que tiene 1 a 10 carbonos, o alquilo sustituido que tiene 1 a 10 carbonos; R4 representa OR8, F, Cl, Br, I, N(R8)2, CO2R8, NO2, NHC(O)R8, metoxilo, alquilo que tiene 1 a 10 carbonos, o alquilo sustituido que tiene 1 a 10 carbonos; R5 y R7 representan
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