Inc.;Proda Biotech LLC;Georgia State University Research Foundation;Georgia State University Research Foundation, Inc.
发明人:
LIU, Zhi-Ren,TURAGA, Chakra, Ravi,YANG, Jenny
申请号：
EP16762256
公开号：
EP3265482A4
申请日:
2016.03.04
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
A non-toxic anti-angiogenesis protein that inhibits tumor growth and exhibits in vitro activity in induction of angiogenic endothelial cell apoptosis without targeting VEGF/VEGFR or any other RTK pathways is described. The protein targets integrins αvβ3, at a groove in the βA domain of β3 formed by α2 helix, B-C loop, and α2-α3 loop.
