Example embodiments may include an apparatus for providing negative-pressure therapy with a push-to-release actuator. The actuator may be a key insertable through a keyway in the apparatus to engage a movable barrier, such as a piston. The actuator may also be used to lock the barrier in a primed position. Pressing on the actuator can release the barrier and activate the apparatus for negative-pressure therapy. In some examples, the actuator may comprise a shaft, a latch, and a spring biasing the latch toward the shaft. The latch may comprise an opening toward a proximal end of the shaft. The apparatus may comprise a receptacle for receiving the actuator, and a keeper may disposed within the receptacle for coupling to the latch. In some embodiments, the keeper may comprise a base protruding from the wall, and a ledge extending from the base toward the second aperture.
