A patient mobility system for early patient ambulation. The system includes a patient support apparatus having a patient support surface supported by a base adapted to rest upon a floor surface. A first actuator may move the patient support deck relative to the base. An ambulation device is removably coupled to the patient support apparatus and includes wheels, a barrier, and a second actuator. The second actuator may move the barrier to a height sufficient to prevent egress of the patient in a coupled configuration, and/or adjust a height of the barrier relative to the wheels in a decoupled configuration so as to provide a grip to support to the patient during ambulation away from the patient support apparatus. A controller may be operable to control at the first and/or second actuators.