The present invention provides the quinazoline compounds with right structural formula: wherein R1 is halogen； R2 is H or halogen； R3 is C1-C3 alkyl a) arbitrarily replaced with halogen； Or b)-(CH2) n- morpholinyls ,-(CH2) n- piperidines ,-(CH2) n- piperazines ,-(CH2) n- piperazines-N (C1-C3 alkyl) ,-(CH2) n- pyrrolidines or-(CH2) n- imidazoles, n are 1 to 4； R4 be-(CH2) m-Het, Het be morpholine, piperidines, piperazine, piperazine-N (C1-C3 alkyl), imidazoles, pyrrolidines, azepane, 3,4- dihydro -2H- pyridines or 3,6- dihydro -2H- pyridines, each is optionally replaced by alkyl, halogen, OH, NH2, NH (C1-C3 alkyl) or N (C1-C3 alkyl) 2； M is 1-3； X is O, S or NH； Or its pharmaceutically acceptable salt, and with preparation method and intermediate compound, useful pharmaceutical compositions and using these compounds treatment proliferative diseases method.本發明提供了具有右面結構式的喹唑啉化合物：其中R1爲鹵素；R2爲H或鹵素；R3爲a)以鹵素任意取代的C1-C3 烷基；或b)-(CH2)n-嗎啉基、-(CH2)n-哌啶、-(CH2)n-哌嗪、-(CH2)n-哌嗪 -N(C1-C3烷基)、-(CH2)n-吡咯烷或-(CH2)n-咪唑，n爲1至4；R4爲 -(CH2)m-Het，Het爲嗎啉、哌啶、哌嗪、哌嗪-N(C1-C3烷基)、咪唑、吡咯烷、azepane、3,4-二氫-2H-吡啶，或3，6-二氫-2H-吡啶，每個都任選被烷基、鹵素、OH、NH2、NH(C1-C3烷基)或N(C1-C3烷基)2取代； m爲1-3；X爲O、S或NH；或其藥學可接受的鹽，以及與其製備方法及中間化合物，有用的藥學組合物及使用這些化合物治療增殖性疾病的方法。
