CRYSTALLINE(2S,4R)-5-(5'-CHLORO-2'-FLUORO-[1,1'-BIPHENY]-4-YL)-2-(ETHOXYMETHYL)-4-(3-HYDROXYISOXAZOLE-5-CARBOXAMIDO)-2-METHYLPENTANOIC ACID AND USES THEREOF
Adam D. Hughes,Melissa Fleury,Miroslav Rapta,Venkat R. Thalladi,Gene Timothy Fass,Michael Simeone,R. Michael Baldwin,David L. Bourdet
申请号：
US15452333
公开号：
US20170275259A1
申请日:
2017.03.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
In one aspect, the invention relates to a crystalline form of the structure:or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crystalline form； methods of using this crystalline form and its soluble form (I)； and processes for preparing soluble (I) and crystalline (I′) forms.
