CRYSTALLINE(2S,4R)-5-(5'-CHLORO-2'-FLUORO-[1,1'-BIPHENY]-4-YL)-2-(ETHOXYMETHYL)-4-(3-HYDROXYISOXAZOLE-5-CARBOXAMIDO)-2-METHYLPENTANOIC ACID AND USES THEREOF
Adam D. Hughes,Melissa Fleury,Miroslav Rapta,Venkat R. Thalladi,Gene Timothy Fass,Michael Simeone,R. Michael Baldwin,David L. Bourdet
申请号:
US15452333
公开号:
US20170275259A1
申请日:
2017.03.07
申请国别(地区):
US
年份:
2017
代理人:
摘要:
In one aspect, the invention relates to a crystalline form of the structure:or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crystalline form; methods of using this crystalline form and its soluble form (I); and processes for preparing soluble (I) and crystalline (I′) forms.