Robert A. Rissman,Kuo-Fen Lee,Wylie W. Vale,Paul E. Sawchenko
申请号：
US12663805
公开号：
US09555032B2
申请日:
2008.06.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods for treating or preventing tauopathies and/or Aβ amyloidosis by modulating CRF receptor signaling. Accumulation of hyperphosphorlyated tau protein in the CNS may be reduced by administration of CRF-R1 selective antagonists and/or CRF-R2 selective agonists. For example, in some aspects, methods for preventing the onset of Alzheimers disease by administration of CRF-R1 selective antagonist are provided.
