Robert A. RISSMAN,Kuo-Fen LEE,Wylie W. VALE, JR.,Paul E. SAWCHENKO
申请号：
US15376205
公开号：
US20170151245A1
申请日:
2016.12.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods for treating or preventing tauopathies and/or Aβ amyloidosis by modulating CRF receptor signaling. Accumulation of hyperphosphorlyated tau protein in the CNS may be reduced by administration of CRF-R1 selective antagonists and/or CRF-R2 selective agonists. For example, in some aspects, methods for preventing the onset of Alzheimers disease by administration of CRF-R1 selective antagonist are provided.
