JASPER JAMMAER,ALEXANDER AERTS,GUY VAN DEN MOOTER,JOHAN MARTENS
申请号：
IN7773/DELNP/2010
公开号：
IN2010DN07773A
申请日:
2010.11.03
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
A new family of ordered mesoporous silica materials denoted COK-10 is synthesized under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and optionally a tetraalkylammonium compound. . The mesopore size is substantially uniform, is in the range 4-30 nm, and can be fine-tuned by adapting the synthesis conditions. A new family of 2D-hexagonal ordered mesoporous silica materials denoted COK-12 is synthesized also under mildly acidic or neutral pH conditions using a combination of an amphiphilic block copolymer and a buffer with a pH greater than 2 and less than 8. The mesopore size is substantially uniform, is in the range of 4 to 12 nm and can be fine-tuned by adapting the synthesis conditions. These ordered mesoporous silica materials are useful as carrier materials for the formulation of poorly soluble drug molecules and for oral drug formulations for immediate release applications.
