OTTAWA HOSPITAL RESEARCH INSTITUTE;CHILDREN'S HOSPITAL OF EASTERN ONTARIO RESEARCH INSTITUTE INC.;MCMASTER UNIVERSITY
发明人:
David F. STOJDL,John Cameron BELL,Brian LICHTY,Jonathan POL
申请号：
US14769035
公开号：
US20160106820A1
申请日:
2014.02.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
There is described a kit for use in inducing an immune response in a mammal, the kit includes: a first virus that expresses MAGEA3, Human Papilloma Virus E6/E7 fusion protein, human Six-Transmembrane Epithelial Antigen of the Prostate protein, or Cancer Testis Antigen 1, or a variant thereof as an antigenic protein and that is formulated to generate an immunity to the protein or variant thereof in the mammal. The kit also includes a Maraba MG1 virus encoding the same antigen, or a variant of the same antigen. The Maraba MG1 virus is formulated to induce the immune response in the mammal. The first virus is immunologically distinct from the Maraba MG1 virus.
