Jean-Baptiste LATOUCHE,Brigitte LE MAUFF QUESTER,Olivier TOUTIRAIS
申请号：
US15780877
公开号：
US20180355316A1
申请日:
2016.12.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to method of amplifying a population of antigen-specific memory CD4+ T cells using artificial presenting cells expressing HLA class II molecules. In particular, the present invention relates to a method of amplifying a population of antigen-specific memory CD4+ T cells comprising the steps of i) providing a population of artificial antigen presenting cells consisting host cells that are genetically modified to stably express at least one MHC class II molecule along with at least one accessory molecule ii) loading the population of artificial antigen presenting cells of step i) with an amount of at least one antigen of interest and iii) coculturing the suitable population of a T cells with the population of artificial antigen presenting cells of step ii).
