חלבונים כימריים מבוססים על l1–pd ו–pd–l2 ושימושים שלהם

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专利权人:

THOMAS JEFFERSON UNIVERSITY

发明人:

申请号：

IL24003415

公开号：

IL240034D0

申请日:

2015.07.20

申请国别(地区):

IL

年份:

2015

代理人:

摘要：

Provided are fusion proteins comprising a first domain and a second domain, wherein the first domain comprises a polypeptide that binds to and triggers PD-1 and the second domain comprises a polypeptide that binds to and triggers a TRAIL receptor or Fas. In some embodiments, the polypeptide that binds to and triggers PD-1 comprises at least a portion of the extracellular domain of PD-L1 or PD-L2 and the second domain comprises at least a portion of the extracellular domain of TRAIL or Fas ligand. Also provided are methods for treating autoimmune, alloimmune or inflammatory diseases, and methods for treating cancer, using the fusion proteins.

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中国工程科技知识中心

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http://www.ckcest.cn/home/