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Maytansinoid derivatives with sulfoxide linker
专利权人:
Nathan Fishkin
发明人:
Nathan Fishkin
申请号:
US14009957
公开号:
US09156854B2
申请日:
2012.03.20
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The invention relates to novel maytansinoid compounds having sulfoxide linkers and more specifically to novel maytansinoid compounds of structural formula (I) and (II). The invention also provides conjugates of the maytansinoid compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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中国工程科技知识中心
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