ISAAC E. MARX,ALESSANDRO BOEZIO,ANGEL GUZMAN-PEREZ,JOHN STELLWAGEN,THOMAS DINEEN,BENJAMIN C. MILGRAM,MATTHEW WEISS
申请号：
ARP160100551
公开号：
AR103833A1
申请日:
2016.03.02
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
1. Claim 1: a formula compound (1),1. A corresponding isomer, acoustic isomer, polyphosphate or mixture thereof, or a pharmaceutically acceptable salt, characterized in that the preparation group (2) is a compound selected from the preparation group (3)；R¹ is a 5, 6, 7, 8, 9, or 10-membered aryl or heteroaryl, or a 3, 4, 5, 6, 7, 8, 9, or 10-membered cycloalkyl or heterocycloalkyl group, wherein the group heteroaryl or heterocycloalkyl may have from 1 to 3 heteroatoms independently selected from O, N or S, or a carbon atom in the cycloalkyl or heterocycloalkyl group may be part of a C = O group, and the aryl, heteroaryl, cycloalkyl group, or heterocycloalkyl is substituted with 0, 1, 2, 3, or 4 substituents independently selected from halo, -CN, -C₁₋₆ alkyl,C₁₋₆ haloalkyl,-OH, -O-C₁₋₆ alkyl,-O-halide c8321c833126；-C (3DO) ORo - (CR R) NR RR2 is lease No. c83217c831832626,or an aryl or heteroaryl of 5, 6, 7, 8, 9, or 10 members, or a cycloalkyl or heterocycloalkyl group of 3, 4, 5, 6, 7, 8, 9, or 10 members, where the heteroaryl group or heterocycloalkyl may have from 1 to 3 heteroatoms independently selected from O, N or S, or a carbon atom in the cycloalkyl or heterocycloalkyl group may be part of a C = O group, and the alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl group is optionally substituted with from 1 to 5 R⁶ substituents independently selected from halo, -CN, -C₁₋₆ alkyl,C₁₋₆ haloalkyl,-OH, -O-C₁₋₆ alkyl,-O-halide c8321c833126；- (CRᵇRᵇ) ₘ-A, -C₂₋₆-A alkenyl, -C₂₋₆-A alkynyl, or -O (CRᵇRᵇ) ₘ-A； each R³ is independently selected from H, -C₁₋₆ alkyl,C₁₋₆ haloalkyl,or halo； each R⁴ is independently selected from H, -C₁₋₆ alkyl,C₁₋₆ haloalkyl,or halo； each R⁵ is independently selected from H, -C₁₋₆ alkyl,C₁₋₆ haloalkyl,A is an Ariel, heterosexual or heterosexual group consisting of 4 to 9 members, or a cyclist or heterosexual group consisting of 3, 4, 5, 6, 7, 8, 9 or 10 members, in which there can be 1 to 3 non orthodox atoms independent of O, n or s；
