5--N-5S-2--3-[4-56--4H-[124]-1-]-13--5--2- NOVEL CRYSTALLINE FORM OF 5-CHLORO-N-5S-2-OXO-3-[4-56-DIHYDRO-4H-[124]TRIAZIN-1-YLPHENYL]-13-OXAZOLIDIN-5-YLMETHYLTHIOPHENE-2-CARBOXAMIDE METHANESULFONATE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
The present invention relates to a process for the preparation of 5-chloro-N- ({(5S) -2-oxo-3- [4- (5,6-dihydro- -1,3-oxazolidin-5-yl} methyl) thiophene-2-carboxamide methanesulfonate, and a pharmaceutical composition comprising the same, wherein the novel crystalline compound according to the present invention is a high- It can be usefully used for preventing or treating diseases such as thrombosis, myocardial infarction, arteriosclerosis, inflammation, stroke, angina pectoris, restenosis after angioplasty, and thromboembolism.본 발명은 5-클로로-N-({(5S)-2-옥소-3-[4-(5,6-디하이드로-4H-[1,2,4]트리아진-1-일)페닐]-1,3-옥사졸리딘-5-일}메틸)티오펜-2-카르복사미드 메탄설폰산염의 신규 결정형 및 이를 포함하는 약학 조성물에 관한 것으로서, 본 발명에 따른 신규 결정형 화합물은 고온 및 가습 환경에서도 우수한 안정성을 나타내므로, 혈전증, 심근 경색, 동맥경화, 염증, 뇌졸중, 협심증, 혈관성형술 후의 재발협착증 및 혈전색전증 등의 질환의 예방 또는 치료에 유용하게 사용될 수 있다.
