Jennifer R. Cochran,Douglas S. Jones, II,Ping-Chuan Tsai
申请号：
US13636053
公开号：
US09556248B2
申请日:
2011.03.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics.
