Richard N. Kolesnick;Jimmy Andrew Rotolo;Wadih Arap;Renata Pasqualini
发明人:
Jimmy Andrew Rotolo,Richard N. Kolesnick,Renata Pasqualini,Wadih Arap
申请号：
US13974405
公开号：
US20140112932A1
申请日:
2013.08.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.
