SHINICHIRO NAKAI,KENICHIRO KIYOSHIMA,MEGUMI IKEDA,SHOHEI HORIUCHI,TOMOMI SATO
申请号：
ARP130102255
公开号：
AR091567A1
申请日:
2013.06.26
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Provided is a Liquid preparation in which the pharmaceutically Active principle is stabilized, and a method for Stabilizing it.A Liquid Preparation comprising a pharmaceutically active substance with a primary or secondary amino Group (where the amino Group is not a part of the structure of amide, an organic acid and a Salt, which is substantially free of a reaction product of princip The pharmaceutically Active and organic acid.Claim 5: Liquid Preparation according to claim 1, wherein the first pharmaceutically Active Compound is a non peptide.Claim 8: Liquid Preparation according to claim 5, wherein the compound is non Peptide 1 - {5 - (2-fluorophenyl) - [1 - (6-methylpyridin-3-yl) sulfonyl] - 1H pyrrole - 3 - il n-methylmethanamine} -, 1 - [4 - - 5 - fluoro - (1 - phenyl - 3 - ilsulfonil pyridin) - 1H pyrrole - 3 - yl] - n-methylmethanamine, N - methyl - 1 - [5 - (4 - methyl - 3 - thienyl) - 1 - (3 - ilsulfonil pyridin -) - 1H pyrrole - 3 - il] metanamina,1 - [5 - (2-fluorophenyl) - 1 - (3 - ilsulfonil pyridin -) - 1H pyrrole - 3 - yl] - n-methylmethanamine, N - methyl - 1 - [5 - (2-methylphenyl) - 1 - (3 - ilsulfonil pyridin -) - 1H pyrrole - 3 - il] metanamina, 1 - (4 - (2 - 5 - fluoro - fluoropiridin - 3 - yl) - 1 - [(2 - 4 - metilpiridin - il) sulfonyl] - 1H pyrrole - il - 3} - n-methylmethanamine, or 1 - [4 - (2 - 5 - fluoro - fluoropiridin - 3 - 1 - (IL) - pyridin - 3 - ilsulfonil) - 1H pyrrole - 3 - yl] - n-methylmethanamine.Claim 11: Liquid Preparation according to claim 1, wherein the organic acid is one or more classes selected from the group consisting of Ascorbic Acid, benzoic acid, sorbic acid, fumaric acid and Maleic acid.Claim 14: Liquid Preparation according to claim 1, wherein the salt is one or more classes selected from the group consisting of Sodium Chloride, Calcium chloride, Magnesium chloride, Sodium bromide, CALCIUM BROMIDE.Claim 22: a Freeze Dried Preparation obtained by lyophilizing the liquid Preparation according to claim 1.Se proporci
