Process for producing Raf kinase inhibitor and intermediate used in the process

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专利权人:

シプラ・リミテッド

发明人:

ドハルマラジェ ラマチャンドラ ラオ,ラジェンドラ ナラヤンラオ カンカン,マルトイ グハガレ,サンドイプ チクハリカル

申请号：

JP2010523590

公开号：

JP5438680B2

申请日:

2008.09.10

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) wherein R' is selected from the group consisting of hydrogen, -C(O)OA, -C(O)CX3, -C(O)NH2, -C(O)-NHOH or There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2-trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.

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