Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y is A is &mdash；(CH2)6&mdash；, cis &mdash；CH2CH&boxH；CH&mdash；(CH2)3&mdash；, or &mdash；CH2C&equiv；C&mdash；(CH2)3&mdash；, wherein 1 or 2 carbon atoms may be substituted with S or O； or A is &mdash；(CH2)m&mdash；Ar&mdash；(CH2)o&mdash； wherein Ar is substituted or unsubstituted phenyl or monocyclic heteroaryl, the sum of m and o is from 1 to 4, and wherein one CH2 may be replaced with S or O； X is S or O； R is a hydrocarbyl or a hydroxyhydrocarbyl moiety having from 1 to 12 carbon atoms； D is independently a moiety comprising from 1 to 6 non-hydrogen atoms； and n is an integer from 0 to 4. Methods, compositions, and medicaments related thereto are also disclosed.
