ENQUIST-NEWMAN, MARIA,VIDANES, GENEVIEVE,HETENYI, KATA ZSUZSANNA
申请号：
CA3078818
公开号：
CA3078818A1
申请日:
2018.09.06
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
[00018] Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ("BIAs") such as thebaine and morphine and their derivatives. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthases and polynucleotides encoding the same, are provided. Further, methods of adjusting pH to optimize the reaction are disclosed.
