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POBLACION DE MICROPARTICULAS QUE COMPRENDEN CORTICOESTEROIDES, PREPARACION DE LIBERACION CONTROLADA, FORMULACION, METODO DE ELABORACION
专利权人:
FLEXION THERAPEUTICS
发明人:
MORAN MARK,KUMAR ANJALI,BODICK NEIL,BLANCKS ROBERT C.,CLAYMAN MICHAEL D.
申请号:
ARP110102807
公开号:
AR082471A1
申请日:
2011.08.03
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
Claim 1: a population of microparticles comprising a corticosteroid Class B, or one of its pharmaceutically acceptable salts,Incorporated in a Matrix of lactic acid - Glycolic Acid Copolymer, where the corticosteroid Class B represents 22% and 28% of the microparticles.Claim 5: the population of claim 1, the preparation of the claim 2 or 3 formulation of the claim,The Copolymer of lactic acid - Glycolic Acid is an Acid Copolymer Poly (lactic co Glycolic) (PLGA).Claim 6: the population of claim 1, the preparation of the claim 2 or 3 formulation of the claim,Where is the corticosteroid Triamcinolone Acetonida Class B or a Chemical Analogue commercial or one of its pharmaceutically acceptable Salts.Claim 12: a population of microparticles comprising a corticosteroid class or one of its pharmaceutically acceptable salts,Incorporated in a Matrix of lactic acid - Glycolic Acid Copolymer, where the corticosteroid Class represents between 15% and 30% of the microparticles.The population of Claims 17: 12 Claims, the preparation of the formulation of the claim or the claim 13 14Where is the corticosteroid prednisolone OR a class a Commercial Chemical Analogue or one of its pharmaceutically acceptable Salts.23: claims a population of microparticles comprising a corticosteroid class C, or one of its pharmaceutically acceptable salts,Incorporated in a Matrix of lactic acid - Glycolic Acid Copolymer, where the corticosteroid class C represents between 15% and 30% of the microparticles.Claim 28: 23 the population of Claims, preparation of the formulation of the claim or the claim 24 25Where C is the class corticosteroid Betamethasone or a Chemical Analogue Commercial, or one of its pharmaceutically acceptable Salts.34: claims a population of microparticles comprising a corticosteroid Class D or one of its pharmaceutically acceptable salts,Incorporated in a Matrix of lactic acid - Glycolic Acid Copolymer, where the corticosteroid Class D is between 8% and 20% of the microparticles.
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