БОДИК Нил (US),БЛЭНКС Роберт С. (US),КУМАР Анджали (US),КЛЕЙМАН Майкл Д. (US),МОРАН Марк (US)
申请号：
RU2013109362/15
公开号：
RU2013109362A
申请日:
2011.08.04
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A population of microparticles containing a class B corticosteroid or a pharmaceutically acceptable salt thereof included in the matrix of a lactic and glycolic acid copolymer in which a class B corticosteroid is from 22% to 28% of the microparticles. 2. The population of claim 1, wherein the copolymer is biodegradable. The population of claim 1, wherein the lactic and glycolic acid copolymer is a poly (lactic-co-glycolic) acid (PLGA) copolymer. The population of claim 1, wherein the class B corticosteroid is triamcilone acetonide or a commercially available chemical analogue or pharmaceutically acceptable salt thereof. The population according to claim 1, in which the microparticles have an average diameter of from 10 μm to 100 μm. The population according to claim 1, in which the copolymer of lactic and glycolic acids is characterized by a molar ratio of lactic acid: glycolic acid in the range from 80:20 to 60: 40.7. The population according to claim 1, in which the copolymer of lactic and glycolic acids is characterized by a molar ratio of lactic acid: glycolic acid 75: 25.8. The population according to claim 1, in which the microparticles also contain a functional group of polyethylene glycol (PEG), where the functional group of PEG is from 25% to 0% by weight of the microparticles. The population of claim 1, wherein the class B corticosteroid is released within 14 days to 90 days. A preparation with controlled or delayed release of a class B corticosteroid, including a microparticle of a lactic and glycolic acid copolymer containing a class B corticosteroid, where class B corticosteroid is from 22% to 28% of the microparticle matrix based on lactic and glycolic acid copolymer. 11. The drug according to claim 10, in which1. Популяция микрочастиц, содержащих кортикостероид класса В или его фармацевтически приемлемую соль, включенные в состав матрицы сополимера молочной и гликолевой кислот, в которой кортикостероид класса В составляет от 22% до 28% микрочастиц.
