The present invention relates to a stable liquid composition comprising an immediate usable use botulinum toxin as an active ingredient without the need for a reconstitution processEspecially when botulinum toxin is contained in low concentration, it is not only able to prevent the Clostridium botulinum toxin agglutination and to show high stabilityIt is effective to prevent adsorption to the container efficiently by batchOr, it relates to the liquid composition which can maintain the activity of the Clostridium botulinum toxin according to the liquid vial.Specifically,Clostridium botulinum toxin(II) L-alanine or methylcellulose(III) containing non ionic surfactant and (IV) bufferThe present invention relates to a liquid composition selectively containing an isotonic.Since the liquid composition of the Clostridium botulinum toxin according to the present invention can be used immediately without the need for the re water purification process, it is possible not only to improve the convenience of the user but also to reduce the activity deviation of the Clostridium botulinum toxin by the dilution error in the rewaterfication process.In addition, the liquid composition according to the present invention is highly effective in preventing the clotting of botulinum toxin even in low botulinum toxin concentration and is very excellent in storage stability, and efficiently prevents adsorption of botulinum toxin into the container by batch or liquid vial The activity of another botulinum toxin is maintained constant.本発明は再水化（ｒｅｃｏｎｓｔｉｔｕｔｉｏｎ）過程を経る必要なしに即時使用可能な（ｒｅａｄｙ－ｔｏ－ｕｓｅ）ボツリヌス毒素を有効成分として含む安定した液状組成物に係り、特にボツリヌス毒素が低濃度で含まれている場合にもボツリヌス毒素の凝集を防止して高い安定性を示すだけでなく、容器への吸着などを効率的に防止してバッチ（ｂａｔｃｈ）別、又は液状バイアル（ｖｉａｌ）別ボツリヌス毒素の活性を一定に維持することができる液状組成物に関するもので、具体的には、（ｉ）有効成分としてボツリヌス毒素、（ｉｉ）Ｌ－アラニン又はメチルセルロース、（ｉｉｉ）非イオン性界面活性剤及び（ｉｖ）緩衝剤を含み、選択的に等張化剤を含む液状組成物に関するものである。本発明によるボツリヌス毒素の液状組成物は再水化過程を経る必要なしに即時使用可能な形態であるので、使用者の便宜性が向上するのみならず、再水化過程での希釈間違いなどによるボツリヌス毒素の活性偏差などを減少させることができる。また、本発明による液状組成物は低いボツリヌス毒素濃度でもボツリヌス毒素の凝集を
