MANUELA MALLY,VERNICA GAMBILLARA,MICHA A. HUPTLE,STEFAN J. KEMMLER,MICHAEL L. WETTER,MICHAEL T. KOWARIK
申请号：
ARP150100534
公开号：
AR100859A1
申请日:
2015.02.23
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Requirement 1: it is composed of E. coli o25b antigen bioaccumulation, covalently docking with prokaryotic protein, E. coli o25b antigen contains formula structure (1),Where n is an integer of one to thirty. 11. Claim 11: a method for inducing the production of eye antibodies specific to Escherichia coli in an experimental subject, including the effective quantity management of the experimental subject according to any one of the requirements 1-8. Claim 18: the host cell referred to in claim 16 or 17, in which the carrier protein is selected from the deoxytoxin group (EPA) of P.aeruginosa,CRM197, Maltese MBP,diphtheria toxoid, tetanus toxoid, S. aureus detoxified hemolysin, agglutination factor A, agglutination factor B, E. coli FHH, E. coli FHH, E. coli heat-labile enterotoxin, detoxified variants of enterotoxin heat-sensitive E. coli, cholera toxin B subunit (CTB),Cholera toxin, detoxification variant of cholera toxin, sat protein of E.coli, temporary dominance of satellite protein of E.coli, pneumococcus pneumoniae of Streptococcus pneumoniae and its toxin variant, acra of C.jejuni and natural glycerin of C.jejuni. 150. Claim 20: a method for preparing n-glicurida carrier protein including o25b antigen of E.coli, comprising: (a) culturing host cells according to any antigen of 16-19； and (b) purifying n-glicurida carrier protein containing o25b antigen of E.coli.Reivindicación 1: Una composición que comprende un bioconjugado de un antígeno O25B de E. coli acoplado covalentemente con una proteína portadora, en donde el antígeno O25B de E. coli comprende la estructura de la fórmula (1), en donde n es un número entero de entre 1 y 30. Reivindicación 11: Un método para inducir la producción de anticuerpos opsonofagocíticos en un sujeto que son específicos de Escherichia coli patogénico extraintestinal, que comprende la administración al sujeto de una cantidad efectiva de la composición de acuerdo con cualquiera de las reivindicaciones 1 - 8. Reivindicación 18: La c
