The present invention relates to a water-borne pressure sensitive adhesive composition, which comprises the polymer copolymerized by the (meth) acrylic acid and its ester-series monomer, the polyoxirane, poly propylene oxide or its copolymer, and selectively therefrom the natto extract, the polyol (such as propylene glycol, glycerine or sorbitol), or the polysaccharide (e.g. chitosan or starch). The water-borne pressure sensitive adhesive composition of the present invention is utilized to make the skin-contact tape such as the drug delivery patch (film) to endow strong adhesiveness towards skin for a long time, without causing skin allergy phenomenon and capable of resulting in the efficacy of long-time and sustainable transdermal drug delivery to the skin surface. The disclosure can also be applied into other application such as the intimate pressure sensitive patch to some private part, without resulting in skin allergy phenomenon.本發明係有關一種水性感壓黏著劑組成物,該組成物包括由(甲基)丙烯酸及其酯系單體共聚合而成之聚合物、聚(環氧乙烷)或聚(環氧丙烷)或其共聚物、及選擇性地一納豆萃取物、多元醇(例如丙二醇、丙三醇或山梨醇等)、多醣體(例如幾丁聚醣或澱粉等)。利用本發明水性感壓黏著劑組成物作成與皮膚接觸之膠布,例如藥膠貼布(膜),對皮膚具有強黏覆力,可以長時間貼覆於皮膚,不會造成皮膚過敏現象,且能對皮膚表面產生長時間與具有持續性的藥物穿皮給藥釋放(Transdermal drug delivery)效果。其他用途的私密貼身感壓膠布也不會造成皮膚過敏現象。