The present invention relates to a water-bone pressure sensitive adhesive composition, which comprises a polymer co-polymerized by (methyl) acrylic acid and its ester monomers, poly(ethylene oxide) or poly(propylene oxide) or their copolymers, and optionally a polyacrylic acid and polysaccharides (such as natto extract or chitosan). With the present invention, the drug sticker cloth (film) made of water-bone pressure sensitive adhesive composition has strong adhesion force, covering a long time of sticking to the skin without causing skin allergies, also can produce a long time and sustained effect of transdermal drug delivery on the surface of the skin.本發明係有關一種水性感壓黏著劑組成物,該組成物包括由(甲基)丙烯酸及其酯系單體共聚合而成之聚合物、聚(環氧乙烷)或聚(環氧丙烷)或其共聚物、及選擇性地一聚丙烯酸、多醣體(例如納豆萃取物或幾丁聚醣)。利用本發明水性感壓黏著劑組成物作成之藥膠貼布(膜),對皮膚具有強黏覆力,可以長時間貼覆於皮膚,不會造成皮膚過敏現象,且能對皮膚表面產生長時間與具有持續性的藥物穿皮給藥釋放(Transdermal drug delivery)效果。